Wire-framing isn't new. You've perhaps used Axure, Balsamiq, ...
Comprehensive projects such as line-of-business applications can have 100s of UI functions and wire-framing them all with those tools can take way too long and prove impractical.
But with VisualSpec prototyping is so fast you can actually do it for the whole project. Also it shortens your feedback cycle to minutes instead of days.